Abstract 15424: Postprandial Lipemia of Coronary Patients is Directly Related to the Number of Criteria of Metabolic Syndrome
Background: Coronary heart disease (CHD) is one of the leading causes of mortality and disability in developed countries. Postprandial lipemia is emerging as a clear determinant of the evolution of the disease.
OBJECTIVES: Our aim was to determine if metabolic syndrome (MetS) traits influence the postprandial lipemia of coronary patients, and if this influence depends on the number of criteria of MetS.
MATERIAL AND METHODS: 1002 patients from the CordioPrev study (NCT00924937) were submitted to an oral fat tolerance test using a High-MUFA weight-adjusted meal (0.7 g fat per kg body weight) with 12% saturated fatty acids (SFA), 10% polyunsaturated fatty acids (PUFA), 43% monounsaturated fatty acids (MUFA), 10% protein and 25% carbohydrates (CHO). Plasma samples obtained during the next 4-hours period were analyzed for lipid parameters. MetS was defined using modified National Cholesterol Education Program guidelines. Area under the curve (AUC) of postprandial lipids parameters were determined by trapezoidal rule.
Results: MetS patients showed higher triglycerides, TG-rich lipoprotein (TRL)-TG and ApoB levels, as well as lower HDL-c and ApoA1 levels, in all points during the postprandial period than non-MetS patients (all, p<0.001). Postprandial lipemia was directly related to the number of criteria of MetS. We found a positive relationship in the number of criteria of MetS with AUC of triglycerides, TG-rich lipoprotein (TRL)-TG, ApoB and glucose, and a negative relationship with AUC of HDL-c and ApoA1 (all, p<0.001).
Conclusion: The existence of MetS influences the postprandial response of carbohydrates and lipids in patients with coronary heart disease in proportion to the number of altered factors.
- © 2013 by American Heart Association, Inc.