Abstract 15376: Serum Neutrophil Gelatinase-Associated Lipocalcin is Independently Associated With Mortality in Acute Coronary Syndromes
Aim: Neutrophil Gelatinase-Associated Lipocalcin (NGAL) is increased in the circulation of patients with cardiovascular (CV) disease, and has been linked to kidney function as well as matrix degradation and inflammation. We hypothesized that circulating NGAL could give prognostic information for patients with acute coronary syndrome (ACS) in addition to Global Registry of Acute Coronary Events (GRACE) score and other established markers.
Methode: We assessed the associations between circulating NGAL, obtained within 24 hours of admission, and mortality, CV mortality, heart failure (HF), reinfarction, stroke and the combined endpoint CV mortality, HF or reinfarction in 1121 patients admitted with ACS.
Results: After adjustment for GRACE score, left ventricular ejection fraction (LVEF), Pro brain natriuretic peptide (BNP), and C-reactive protein (CRP), NGAL was associated with mortality (hazard ratio [HR] 1.41, p=0.02 ) and the combined endpoint (HR 1.45, p=0.006) during long-term follow-up (median 91 months). NGAL was also significantly associated with the short-term (3 months) and late long term (median 129 months) mortality after adjustment (short term HR 2.76, p=0.005, late long term HR 1.51, p<0.001).
Conclusion: NGAL is associated with both short and long term prognosis of patients with ACS independently of GRACE score, BNP, CRP and LVEF. NGAL could therefore potentially improve selection of patients needing closer follow up after admission to hospital for ACS.
- © 2013 by American Heart Association, Inc.