Abstract 15357: Statin Use is Associated With Decreased Vigorous Physical Activity in Individuals With Hyperlipidemia
Background: Physical activity and pharmacotherapy with statins are two effective ways to reduce the risk of cardiovascular disease. Statins, however, may impair muscle physiology and have been observed to cause skeletal muscle myopathy, impaired muscle mitochondrial function and oxidative capacity, and impaired cardiorespiratory adaptation. We assess the hypothesis that statin usage might be associated with decreased vigorous physical activity in individuals with hyperlipidemia.
METHODS: In a cross-sectional study of patients with hyperlipidemia from the National Health and Nutrition Examination Survey (NHANES) spanning from 2001 to 2010, we built two multivariate logistic models to assess the odds of engaging in vigorous and moderate physical activity, in hyperlipidemic subjects who use (vs. do not use) statins. Vigorous activity was defined as >10 minutes of physical activity causing heavy sweating or large increases in breathing or heart rate. Moderate activity was defined as >10 minutes of physical activity causing only light sweating or slight to moderate increase in breathing or heart rate. We adjusted for socio-demographics, comorbidities and other risk factors.
RESULTS: In this study of 7,688 hyperlipidemic subjects, (51.2% female, 77% white, 50% 44-64 years old) about half had hypertension, most had a BMI≥25 and 36% were on statins. Statin use was associated with a statistically significant 16% (p=0.020) decrease in the odds of vigorous but not moderate physical activity. Hypertension (OR=.81, p=0.01), diabetes (OR=.78, p=0.003), heart disease (OR=.80, p=0.03), smoking (OR=.73, p=0.004) and BMI≥25 (OR=.79, p=0.003) also had significantly negative effects on vigorous activity. However, having health insurance (OR=1.27, p=0.03), a college education (OR=1.75, p<0.0001), and higher income (OR=1.49, p=0.002) increased the odds of vigorous physical activity.
Conclusions: These results suggest that statin exposure in hyperlipidemic subjects may reduce the odds of engaging in vigorous physical activity. The results may be explained by the myocyte dysfunction commonly attributed to statins. Replication of this finding in longitudinal studies, designed to explore causation, may be of great public health and clinical relevance.
- © 2013 by American Heart Association, Inc.