Abstract 15350: The Relationship Between the Volume of Epicardial Adipose Tissue and the Infarct Size in Patients With a First STEMI: Cardiac MRI Study
Purpose: Epicardial adipose tissue (EAT), which is the visceral fat deposited around the heart, has been considered as an endocrine organ, and it secretes pro-inflammatory and anti-inflammatory cytokines and chemokines. EAT has been reported to have the association with the presence of coronary artery disease. However the association between EAT volume and infarct size has not been established in patients with ST-segment elevation myocardial infarction (STEMI).
Methods: Eighty one patients (age=64±12 years) with a first STEMI reperfused within 12 hours after the onset (LAD=41, RCA=32, LCX=8, peak-CPK=3,054±2,459 U/l) were included. EAT volume and infarct size were assessed by cardiac magnetic resonance imaging (CMR) including late gadolinium enhancement (LGE) at 9±4 days using 1.5T MAGNETOM Avanto (SIEMENS), and analyzed using Q-MASS MR ver 7.5 (Medis). EAT volume was calculated by tracing on consecutive end-diastolic short-axis images (Fig).
Results: There were no clinical differences in relation to the level of their EAT volume without body mass index (BMI). EAT volume was negatively correlated with infarct size (Fig), although the other parameters of ‘adipose’ (waist circumference, BMI, metabolic syndrome, mean intima-media thickness of common carotid artery) weren’t correlated with infarct size (all, p=ns). Neither visceral adipose nor subcutaneous adipose measured by CT were correlated with infarct size (p=ns). Higher EAT volume was associated with good collaterals defined as Rentrop 2 or 3 (P=0.04) at their initial angiography. Accordingly we think that these relationships may explain our result.
Conclusions: Higher volume of EAT was associated with smaller infarct size in patients with a first STEMI. EAT may stimulate collaterals and contribute smaller infarct size.
- © 2013 by American Heart Association, Inc.