Abstract 15329: Cardiovascular Protective Effect of Renal Sympathetic Denervation Independently of Blood Pressure Control
AIM: Recent studies have demonstrated the effectiveness of catheter-based renal sympathetic denervation in reducing blood pressure in patients with resistant hypertension. The aim of this study was to investigate the protective effects of renal sympathetic denervation on cardiovascular desease.
METHODS: Nine-week-old salt-loaded stroke-prone spontaneously hypertensive rats (SHRSP) were divided into five groups: (1) low salt diet, (2) high salt diet, (3) high salt diet with sham operation, (4) high salt diet with bilateral renal denervation (BRD), and (5) high salt diet on hydralazine treatment (5mg/kg/day). All rats were sacrificed at four weeks after these treatments.
RESULTS: Blood pressure, heart weight, left ventricular (LV) interstitial fibrosis and macrophage infiltration of high salt diet group were significantly increased compared to low salt diet group. Acetylcholine-induced vascular endothelium-dependent relaxation in high salt diet group was significantly deteriorated compared to low salt diet group. BRD and hydralazine treatment significantly reduced the increase of blood pressure induced by salt load, and there were no significant differences in blood pressure between the BRD and hydralazine treatment groups. BRD treatment more significantly suppressed the increase of heart weight and the progression of left ventricular interstitial fibrosis and macrophage infiltration induced by salt load compared to hydralazine treatment. Simiraly, BRD treatment more significantly ameliorated the impairment of vascular endothelium-dependent relaxation induced by salt load compared to hydralazine treatment.
CONCLUSION: BRD suppressed the salt induced progression of LV hypertrophy, LV interstitial fibrosis, macrophage infiltration and the impairment of vascular endothelial function independent of blood pressure control. These findings indicate the pleiotropic protective effect of BRD on cardiovascular desease.
- © 2013 by American Heart Association, Inc.