Abstract 15287: Left Ventricular Non Compaction 1997-2013: Seventeen Years Later. Morbidity and Risk Factors for Death or Transplant
Background: Controversy exists around LVNC due to challenges in diagnosis, small cohorts, and short-term follow up. The purpose of this study was to review our institutional cohort 17 years later and determine natural history and long-term therapeutic interventions.
Methods: Retrospective cohort study of 36 children with LVNC diagnosed at Texas Children’s Hospital from 01/1997 to 01/2013.
Results: Of 36 patients (pts), there were 24 (67%) survivors (17 followed at TCH and 6 were contacted via survey). 10(28%) deaths, and 6% lost to follow up.Of survivors, ventricular dysfunction (EF <55%) was noted in 9 (39%) and 4 (11%) had undergone a heart transplant (with 1pt requiring LVAD). All pts with an EF <55% were on a heart failure medication (enalapril (100%), carvedilol (33%) or others (22%). An arrhythmia/abnormal ECG was found in 7(19%) of all pts of which 3(8%) underwent AICD placement for arrhythmias. Phenotype switching from LVNC to a Dilated/Hypertrophic type was noted on 6%. Of the 23 survivors, 39% were involved in non-competitive sports and no pregnancies were reported.
Conclusions: We described the longest follow up of pediatric LVNC patients and depict risk factors for death or heart transplantation.LVNC has the potential to create a continuing burden on patients and health care system, requiring further research to improve long term outcomes.
- © 2013 by American Heart Association, Inc.