Abstract 15229: Impact of Age on Strut Coverage and Neointimal Response to Sirolimus Eluting Stent
Background: Recent studies reported that older age is associated with adverse outcomes in patients undergoing percutaneous coronary intervention (PCI).
Methods: A total of 119 patients with 120 sirolimus eluting stents (SES) were divided into 3 groups according to their age: Group 1, age≤55 years (46 stents in 46 patients); Group 2, 56 to 65years (39 stents in 39 patients); and Group 3, >65 years (35 stents in 34 patients). We assessed the strut coverage and neointimal response at 6-month and 12-month follow-up.
Results: Both at 6-month and at 12-month follow-up, the elderly patients had high proportion of uncovered struts and lower proportion of struts embedding. The thickness and area were also different in different groups. At 6-month, as the age increased, the proportion of uncovered struts increased: 6.1% vs. 7.3% vs. 11.7% (P<0.001), and the proportion of embedded struts decreased 72.1% vs. 57.0% vs. 55.0% (P<0.001). Mean neointimal thickness (NIT) were 90μm vs. 60μm vs. 60μm (P<0.001), and the neointimal area were 0.82mm2 vs. 0.52mm2 vs. 0.57mm2 (P<0.001). At 12-month follow-up, as the age increased, the proportion of uncovered struts were 3.9% vs. 3.3% vs. 4.9% (P<0.001), and the mean NIT was 100μm vs. 70μm vs. 80μm (P<0.001), and the neointimal area was 0.87 mm2 vs. 0.60 mm2 vs. 0.67 mm2 (P<0.001).
Conclusions: This optical coherence tomography study found the younger (age≤55years old) had a good strut coverage and neointimal response compared with the older and elderly patients after sirolimus eluting stent implanted.
- © 2013 by American Heart Association, Inc.