Abstract 15209: Targeted Injection of Gold Nanorods Improves Left Ventricular Function Post Myocardial Infarction
Background: A major cause of heart failure is LV pump dysfunction which progressively develops following a myocardial infarction (MI). The “tipping point” in this process has been termed LV remodeling as defined as progressive LV dilation and MI thinning. While cell and gene based therapies have demonstrated this post-MI remodeling process is modifiable, alternative approaches such as the injection of bioengineered negatively charged gold nanorods (AuNRs), have not been evaluated.
Methods/Results: Adult pigs underwent MI induction (coronary ligation) and were randomized to undergo AuNR injections (MI/AuNR; n=8; 9 injections 1x109 AuNR/injection) or MI Only (n=7). LV function and geometry were serially assessed by echocardiography (pre-MI [baseline] and at 7 and 14 days post-MI). By 14 days post-MI, LV ejection fraction fell and MI wall thickness decreased in both groups, but these changes were significantly attenuated in the MI/AuNR group. Moreover, the rate of LV dilation was significantly diminished with targeted AuNR injections (Figure). Left atrial area, a reflection of the magnitude and progression of heart failure, increased by 63% in the MI Only group but only by 28% (p<0.05) in the MI/AuNR group. Finally, indices of inflammation within the MI region, such as expression of tumor necrosis factor (TNF), were reduced in the MI/AuNR group vs. MI Only (0.5+0.1 vs. 1.4+0.4 Δ CT; p<0.05).
Conclusion: These results demonstrate for the first time that targeted gold nanorod injections significantly attenuated adverse LV remodeling post-MI as well as indices of LV failure and was associated with reduced indices of inflammation. These findings demonstrate that targeted injection of bioengineered gold nanoparticles within the MI region may be a novel therapeutic strategy.
- © 2013 by American Heart Association, Inc.