Abstract 15181: Left Main Calcified Lesions as a Strong Predictor of All-Cause Death
Introduction: Currently, coronary artery calcium (CAC) score is well recognized and recommended as level 2A for risk stratification in asymptomatic patients at intermediate risk. In this study, considering all patients with CAC score at Harbor-UCLA medical center since 1991, we examined the predictive power of number of calcified lesions with all-cause mortality.
Method: We examined 30567 patients with a clinical referral for a CAC score. After exclusion of cases with age less than 40, history of CABG or PCI, and those with missing values, a total of 12599 cases remained. We considered all-cause death as the outcome of our study as determined by a search of the Death Master File in 1/2013. Based on the CAC scores, patients were divided into four groups of zero, one to 100, 101 to 400, and more than 400. Moreover, Self-reported hypertension, dyslipidemia, Diabetes, Smoking and familial history of premature CAD were considered as risk factors of CAD.
Result: In total, 4251female and 8348 male with mean age of 59±10 were enrolled. Among them 614 individuals died. Mean scan-death time interval was 4.8±3 years. In total, 34.8% of all individuals had no calcified plaque. Considering Age at scan, Gender, number of risk factors, type of involved vessels and CAC scores in Cox regression analyses revealed, calcified Left main lesion was the a strong independent predictor of all-cause mortality (See table).
Conclusion: Left Main calcification was a strong predictor of All-cause Death, stronger than a one category change in CAC score Table- Cox Regression Analysis; End event of All Cause Death
- © 2013 by American Heart Association, Inc.