Abstract 15056: Relation of Epicardial and Intrathoracic Adipose Tissue Volume With Metabolic Syndrome Among Type 1 Diabetic Patients in DCCT/EDIC
Introduction: Patients with diabetes and metabolic syndrome are susceptible to coronary artery disease (CAD). Epicardial adipose tissue (EAT) and intrathoracic adipose tissue (IAT) have a close interaction with CAD. In this pilot study we sought to examine the relation between EAT and IAT volumes with presence or absence of metabolic syndrome (MetS) among type 1 diabetes mellitus (T1DM) patients.
Method: We measured 100 participants who had access on EAT and IAT volumes data from 1205 patients who underwent non-contrast cardiac computed tomography (CT) in Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) study. MetS was defined as diabetes plus at least two other abnormalities: waist circumference ≥88 cm in women and ≥102 cm in men, triglycerides ≥ 150mg/dl, HDL cholesterol < 50 mg/dl in women and < 40 mg/dl in men, blood pressure ≥ 130/85 mmHg or use of any anti-hypertensive medication. EAT and IAT volumes were measured by CT. Fat was defined as all pixels with density of -30 to -190 Hounsfield Unit. The associations between EAT and IAT volumes and MetS were evaluated using multiple linear regression models adjusting for gender and age.
Results: Of the 100 patients, aged 44 years old (range 32-57), 78% were male, and 19% had MetS. The mean ± SD of EAT and IAT were 34 ± 15 and 41 ± 20 in women and 45± 17 and 62 ± 27 mm3 in men, respectively with a significant difference between genders (p<0.01). Patients with MetS had significantly higher EAT and IAT volumes after adjusting for gender and age (both p < 0.0001). The significance of differences in fat volumes remained strong after further adjusting for mean HbA1c during DCCT/EDIC in both EAT and IAT volumes (MetS presence-absence 17.6±3.9and 23.0±6.2 mm3, in order; P<0.0001).
Conclusion: T1DM with MetS had significantly higher EAT and IAT volumes.
- © 2013 by American Heart Association, Inc.