Abstract 14957: Birth Weight and the Risk of Type 2 Diabetes Mellitus in Postmenopausal Women
Background: Evidence suggests that low birth weight (LBW) due to in-utero programming is associated with a higher risk for type 2 diabetes (T2DM) in adulthood. Prior studies focused on Caucasian populations with few examining the relationship of LBW on T2DM in well powered cohorts of other racial and ethnic groups.
Methods: We examined the association between four self-reported categories of birth weight and T2DM in participants from the Women’s Health Initiative (WHI) Observational Study (OS). We defined prevalent T2DM at baseline as participants with a self-report of physician diagnosis of ‘sugar diabetes when not pregnant’ including those that were taking pills for diabetes or receiving insulin shots. Controls were defined as women with no self-report of diabetes. Women who reported that they were a twin or triplet or were born 4 or more weeks premature were excluded. Logistic regression of T2DM and birth weight was performed adjusting for age and ethnicity at baseline. Analyses included all participants and stratified by race.
Results: Birth weight of <6 lbs. (OR=1.35, 95% CI=1.21-1.50) was significantly associated with self-reported T2DM compared to women who reported their birth weight between 6 and 7 lbs. 15 oz. Stratifying by race, birth weight of <6 lbs. was associated with T2DM in both White (OR=1.43, 95% CI=1.25-1.62) and Black (OR=1.31, 95% CI=1.04-1.64) women. A significant trend was observed in Hispanic women where increasing birth weight was associated with decreasing T2DM prevalence (P=0.04) whereas in Asian women increasing birth weight was associated with increasing T2DM prevalence (P=0.03).
Conclusions: A birth weight of <6 lbs. is associated with increased risk for T2DM in adulthood for White and Black postmenopausal women. To our knowledge this is the largest study of birth weight and T2DM in a multi-ethnic cohort of women to-date.
- © 2013 by American Heart Association, Inc.