Abstract 14905: Change in Left Ventricular Longitudinal Function is Related to Change in Left Ventricular Noncompaction Layer Volume in Patients With Left Ventricular Noncompaction Cardiomyopathy
Introduction: Case reports have demonstrated that patients with left ventricular (LV) systolic dysfuction fullfilled LV noncompaction (NC) criteria showed regression of LVNC appearance after optimal medical therapy and/or device therapy.
Hypothesis: We hypothesized that the NC layer (NCL) regression ocuured associated with improvement in LV longitudinal function in patients with LVNC cardiomyopathy.
Methods: We prospectively examined 24 consecutive patients with LVNC cardiomyopathy. All patients underwent standard, Doppler flow, and global longitudinal strain by speckle tracking echocardiography (Vivid 7, GE Healthcare). All patients received optimal medical therapy and/or cardiac resynchronization therapy. The duration of follow-up observation was 31.3 months (range, 9-82 months). LV volumes were traced manually and assessed using biplane method. The volumes of NCL were caluculated by the subtraction from the volumes of outer layer of NCL to the volumes of inner layer of NCL. LV reverse remodeling was defined as an absolute increase in LV ejection fraction more than 10% at follow-up
Results: Ten patients (41.6%) showed LV reverse remodeling at follow-up. The volume of NCL reduced from 55 ± 29 ml to 33 ± 20 ml. The mean LV ejection fraction improved from 27 ± 8 % to 35 ± 13% and the mean LV global longitudinal strain GLS improved from -6.9 ± 2.6 % to -8.3 ± 3.1%. Changes in NCL showed significant correlation with changes in LV global longitudinal strain (r = 0.51, P = 0.011) and LVEF (r = - 0.45, P = 0.027).
Conclusions: Change in NCL volume is related to change in LV global longitudinal strain and LV ejection fraction in patients with NC cardiomyopathy after optimal medical therapy and/or cardiac resynchronization therapy. The endomyocardial dysfunction, which contributes to longitudinal LV dysfunction, may be related to LV noncompaction appearance.
- © 2013 by American Heart Association, Inc.