Abstract 14844: Lipoprotein (a) Does Not Show Significant Effect for the Development of Aortic Stenosis in Japanese
Background: Genetic variation in the LPA locus, mediated by Lp(a) levels, has been reported to be associated with incident clinical aortic stenosis. The aim of this study is to clarify the effect of Lp(a) for the development of AS in Japanese population.
Methods and Results: We investigated 104 AS patients who had aortic valve area (AVA) <1.8 cm2, and whose laboratory data and echocardiography data were taken on same day. Mean aortic valve peak velocity was 3.2±1.1 m/s, mean gradient was 25.5±21.3 mmHg, and AVA by continuity equation was 1.05±0.42 cm2 in those patients. We selected age- and sex-matched normal control (n=80), and compared with 80 out of the 104 AS patients. Mean ages were similar in both groups (74.7±7.3 years in AS patients, 74.1±6.9 years in control, ns). B-type natriuretic peptide was 157.4±188.3 pg/ml in AS patients and 38.7±23.0 pg/ml in control (p<0.0001). Hemoglobin A1c was 5.88±1.06% in AS patients and 5.46±0.45% in control (p=0.0028). The level of Lp(a) was 18.3±16.1 mg/dl in AS patients, and that of control was 16.5±15.0 mg/dl (n.s). Among AS patients, there were not significant correlations between Lp(a) and AVA (R=0.012, p=ns), and/or aortic valve peak velocity (R=0.098, p=ns). Then we divided AS patients into mild to moderate AS-group (n=53) and severe AS-group (n=51) by the cutoff value of AVA; 1.0 cm2. There were not significant differnces of Lp(a) levels between these two groups (mild-moderate AS group; 20.2±17.5mg/dl, severe AS group; 19.4±17.6mg/dl, p=ns). We compared the Lp(a)/total cholesterol, Lp(a)/HDL-cholesterol and Lp(a)/LDL-cholesterol between these two groups, and there were no significant differences.
Concluion: Lp (a) dose not show significant effect for the developement of AS in Japanese population.
- © 2013 by American Heart Association, Inc.