Abstract 14802: Osteoprotegerin and Osteopontin Serum Levels Are Associated With Arterial Wall Properties and Interleukin-6 Serum Levels in Patients With Coronary Artery Disease
Background: Osteoprotegerin (OPG) and osteopontin (OPN) have recently emerged as key factors in both vascular remodeling and atherosclerosis progression. Interleukin-6 is a well established inflammatory marker contributing to the development of atherosclerosis. Endothelial function and arterial stiffness are key players in the pathophysiology of atherosclerotic disease and measurement of endothelial function and arterial stiffness is a strong predictor of adverse cardiovascular outcomes. We evaluated the relation of OPG, OPN, and Interleukin-6 serum levels with vascular function in patients with coronary artery disease (CAD).
Methods: We enrolled 280 patients with stable CAD (mean aged 61±11years), and 129 control subjects (mean aged 60±12 years). OPG, OPN and Interleukin-6 serum levels were measured using ELISA. Endothelial function was evaluated by flow mediated dilation (FMD) in the brachial artery and carotid-femoral pulse wave velocity (PWV) was measured as an index of aortic stiffness.
Results: There was no significant difference between control subjects and CAD patients according to age and sex. Compared to control subjects, CAD patients had significantly impaired FMD (p<0.001) and increased PWV (p=0.006). CAD patients had also significantly higher levels of OPG (3.91±1.87 pmol/l vs. 2.88±2.17 pmol/l, p<0.001), logOPN (1.81±0.18 ng/ml vs. 1.71±0.24 ng/ml, p<0.001) and logInterleukin-6 (0.44±0.44 pg/ml vs. 0.25±0.31 pg/ml, p=0.006), compared to control subjects. More importantly, PWV were positively associated with serum OPG levels (r=0.19, p<0.01), serum logOPN levels (r=0.10 p=0.049) and log Interleukin-6 levels (r=0.21, p=0.008) and FMD was negatively associated with OPG levels (r=-0.126, p=0.048). Finally, logInterleukin-6 levels were associated with logOPN and OPG serum levels (r=0.19, p=0.02 and r=0.21, p=0.008, respectively).
Conclusions: Our findings indicate that CAD patients have increased OPG, OPN and Interleukin-6 levels. Moreover, there is a consistent association between OPG and OPN serum levels, vascular function and inflammation in CAD patients. These findings suggest another possible mechanism linking OPG and OPN serum levels with CAD progression through arterial wall stiffening and inflammation.
- © 2013 by American Heart Association, Inc.