Abstract 14763: Associations of Depressive Symptoms With Metabolic Syndrome: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
Background: Studies examining the relationship between depression and presence of metabolic syndrome (MetS) show mixed findings. Previous longitudinal studies do not account for the possibility that participants’ metabolic syndrome status or depressive symptoms status could change across examinations. Objective: To longitudinally examine effects of depressive symptoms and changes in depressive symptoms over time on metabolic syndrome in black and white men and women.
Methods: Participants from the Coronary Artery Risk Development in Young Adults (CARDIA) Study who participated in the Year 10 exam in 1995 and had depressive symptoms and metabolic syndrome scores measured between 1995 and 2010 were included in the analysis (n=3,892). Depressive symptoms were determined using the Centers for Epidemiologic Study Depression score (CES-D). Anthropometric and cardiovascular risk factors were measured; MetS was defined using NCEP/ATPIII criteria. Repeated measures regression models adjusted for age, income, alcohol intake, physical activity, smoking status and antidepressant use.
Results: At baseline (Year 10), participants’ mean age was 35 years (SD=3.7), mean depressive symptoms score was 10.7 (SD=8.2), and 11% had metabolic syndrome. Participants with higher average depressive symptom scores were more likely to have metabolic syndrome (OR 1.03, CI: 1.02, 1.04 per 1 unit higher). However, when stratified by race and gender, associations were found in black (OR 1.03, CI: 1.01, 1.04) and white women (OR 1.05, CI: 1.03, 1.07), whereas there was no association among black (OR 1.01, CI: 0.99, 1.03) or white (OR 1.02, CI: 1.00, 1.05) men. Changes in depressive symptoms over time were not associated with MetS (OR 0.99, CI: 0.99, 1.00).
Conclusion: Depressive symptoms were associated with metabolic syndrome among women but not men; race did not influence the relationship. In conclusion, depressive symptoms may contribute to the presence of metabolic syndrome, an established risk factor for CHD and diabetes, particularly in women.
- © 2013 by American Heart Association, Inc.