Abstract 14736: NT-proBNP but Not Soluble Corin Levels Were Associated With Preeclampsia in Pregnancy-Associated Hypertension
Objective: Corin is a serine protease known to convert B-type natriuretic peptide (BNP) prohormone into BNP and its amino terminal fragment (NT-proBNP). In mice lacking corin, high blood pressure and proteinuria were found at late gestational stages, with associated delayed trophoblast invasion and impaired spiral artery remodeling in the uterus.
Hypothesis: We hypothesize that both elevated NT-proBNP and soluble corin levels predict the presence of preeclampsia in pregnant patients with hypertension.
Methods: We prospectively enrolled 149 pregnant women with a history of chronic hypertension or gestational hypertension presenting at a tertiary-care hospital. We measured plasma NT-proBNP and soluble corin levels, and patients were divided into two groups based on the preeclamptic status.
Results: In our study cohort, 62(41.6%) patients with preeclampsia had lower gestational age than patients without preeclampsia (33.3±3 versus 36.6±3 weeks; p<0.001), otherwise they had similar baseline characteristics. We observed higher NT-proBNP levels in patients with preeclampsia compared to those without preclampsia (414±485 vs 145±222 pg/mL, p<0.001), with no differences between chronic and gestational hypertension (432±440 versus 409±503 pg/mL, p=0.85). However, the level of corin was not statistically different between the two groups(1,819±743 vs 1,602±547, p=0.06). ROC curve analysis demonstrated stronger predictive value of NT-proBNP compared to soluble corin in predicting the presence of preeclampsia in our study population (AUC 0.74 vs 0.58, Figure).
Conclusion: In our study cohort of patients with pregnancy-associated hypertension, circulating NT-proBNP but not soluble corin levels were associated with preeclampsia. While corin may contribute to mechanistic underpinnings of the development of preeclampsia in animal models, soluble corin likely has no diagnostic role in human for preeclampsia beyond natriuretic peptide levels.
- © 2013 by American Heart Association, Inc.