Abstract 147: Vasodilatory Effect of Ginseng After Resuscitation From Cardiac Arrest
Background: We have previously shown in a rat model of cardiac resuscitation that sodium hydrogen exchanger-1 (NHE-1) inhibition was associated with preservation of left ventricular distensibility during chest compression, improvement in post-resuscitation myocardial function, and greater survival. We hypothesized that ginseng, which has the ability to inhibit NHE-1, could improve resuscitability and survival during resuscitation after cardiac arrest.
Methods: Male Sprague-Dawley rats were randomized in blocks of 2 to receive ginseng extract (Panax quinquefolius, 0.9 g/L) in drinking water or sham, provided ad libitum, starting 5 days before the experiments. Ten rats in each group were subjected to 8 minutes of VF. Resuscitation was attempted by 8 minutes of chest compression and electrical shocks. Resuscitated rats were observed for 180 minutes.
Results: During chest compression the ratio between coronary perfusion pressure and chest compression depth, an indicator of left ventricular distensibility, was comparable between groups. However, a trend towards higher resuscitation rates was observed in the ginseng group (90% vs 60%, p=NS). During post-resuscitation, significantly lower mean aortic pressure (MAP) and systemic vascular resistance index (SVRI) was observed in the ginseng group indicating a vasodilatory effect (Figure). No differences in cardiac work index (CWI) were observed between groups. A trend in survival was observed favoring ginseng (70% vs 50%, p=0.325 by Log-rank test).
Conclusion: Ginseng showed a trend towards improvement in resuscitation and survival despite no improvement in left ventricular distensibility or post-resuscitation myocardial function, a characteristic feature of NHE-1 inhibitors. Further research is needed to understand the vasodilatory effects and validate (or reject) the favorable trend on resuscitation and survival.
- © 2013 by American Heart Association, Inc.