Abstract 14670: Distinct Morphologic and Functional Characteristics of Carotid Arteries in Patients With Diabetes Mellitus and Coronary Artery Disease
Background: Inflammation has a pivotal role in the progression of atherosclerosis and seems to be pronounced in patients with diabetes mellitus (DM). Microwave radiometry (MR) is a new noninvasive method, which allows the in vivo measurement of the internal temperature of tissues reflecting inflammation. We evaluated the impact of DM on carotid artery inflammation in patients with CAD on a vessel- and patient based analysis.
Methods: We included 271 consecutive patients (n=542 carotids) with significant CAD documented by coronary angiography. All patients underwent carotid artery examination by basic ultrasound imaging and MR. During ultrasound study maximum IMT of carotid arteries was determined. IMTmax was assigned for each patient as the maximal IMT value of both carotid arteries. Respectively, temperature difference (ΔT) by MR was assigned as maximal temperature along each carotid artery minus minimum. ΔT≥0.90°C was assigned as high ΔT. ΔTmax was assigned as the maximal ΔT value of both arteries. Vessel- and patient based analysis was performed to determine the impact of DM on morphological and functional characteristics of carotid arteries.
Results: From the 271 patients 104 (38.38%) had DM. In vessel-based analysis, mean IMT was similar between patients with DM and patients without DM (1.92±0.93 vs 2.09±1.15 mm, p=0.06). Mean ΔT was higher in carotid arteries of patients with DM (0.87±0.25 vs 0.76±0.22 oC, p=0.01). In multivariate logistic regression analysis, DM was an independent predictor of high ΔT unilaterally (p=0.05, OR=1.56, 95% CI: 1.00-2.53).
In patient-based analysis ΔTmax was higher in patients with DM in comparison to patients without DM (1.06±0.52 vs 0.93±0.46oC, p=0.03). In contrast, in patients without DM higher IMTmax was found (2.50±1.63 vs 2.22±0.91mm, p=0.05). In multivariate logistic regression analysis, DM was an independent predictor for the presence of high ΔT bilaterally (p=0.05, OR: 1.85, 95% CI 1.00-3.44).
Conclusions: In patients with CAD and DM, a divergence between structural and functional characteristics of carotid arteries was noticed. Microwave radiometry thus, may serve as an additional tool for the estimation of functional plaque characteristics.
- © 2013 by American Heart Association, Inc.