Abstract 14657: Comparison of the Seattle Angina Questionnaire With Daily Angina Diary Entry
Background: The Seattle Angina Questionnaire (SAQ), a widely-used CAD-specific health status tool, has not been validated against daily records of angina frequency and sublingual nitroglycerin (SL NTG) use. Evidence about the validity of the SAQ could justify its broader use as an outcome for clinical studies designed to evaluate treatments that improve patients’ symptoms, function and quality of life.
Methods: We used data from patients with type 2 diabetes, CAD, and stable angina from the multinational TERISA trial. The number of angina episodes and SL NTG used were recorded and transmitted daily with an electronic diary. We compared the SAQ (4-week recall) cross-sectionally with the preceding 4 weeks of patients’ diaries, focusing on the 2 corresponding SAQ Angina Frequency (AF) questions (i.e., frequency of angina and SL NTG use). Longitudinal change in SAQ AF scores from baseline to 8 weeks was compared with changes in diary responses over the corresponding time period. Analyses were also stratified by age, sex, and geography.
Results: Of 949 randomized subjects, 917 had complete diary and SAQ data; mean age 64 years, 61% men. There was a strong relationship between the 2 SAQ AF questions and the corresponding diary responses (Figure), with correlations of -0.56 for angina frequency and -0.51 for SL NTG use (p<0.0001 for both). Correlations were similar when stratified by age, sex, or geography (-0.53 to -0.63 for angina; -0.48 to -0.55 for SL NTG; p<0.0001 for all). Changes in SAQ AF scores from baseline to 8 weeks also correlated with changes in angina frequency (-0.40) and SL NTG use by diary (-0.32; p<0.0001 for both).
Conclusion: In a multinational cohort of patients with stable angina, the SAQ AF domain was strongly correlated cross-sectionally and moderately correlated longitudinally with daily diary entry of angina frequency and SL NTG use. These data further support the validity of the SAQ AF domain across a broad spectrum of patients with stable angina.
- © 2013 by American Heart Association, Inc.