Abstract 14620: The Effect of Intra-Coronary Nicorandil Administration Prior to Reperfusion in Acute ST Segment Elevation Myocardial Infarction
Intravenous nicorandil infusion with percutaneous coronary intervention (PCI) has been reported to reduce reperfusion injury events and improve cardiac function in patients with acute myocardial infarction.
We assessed the hypothesis that administration of intracoronary nicorandil prior to revascularization could have the similar beneficial effect on acute myocardial infarction.
Seventy-three patients with acute ST segment elevation myocardial infarction receiving PCI were randomly assigned to the Nicorandil Group (n=37) or the Control Group (n=36). The composite endpoints were the incidence of a ventricular arrhythmia, no-reflow and slow flow. A significant differences in the composite endpoint was observed in the Nicorandil Group compared to the Control Group (p=0.037). The occurrence of post TIMI grade 3 was significantly higher in the Nicorandil Group (p=0.019). Major adverse cardiac events during hospitalization and within 30 days of treatment were similar between the two groups.In conclusion, administration of intracoronary nicorandil reduced the occurrence of no-reflow, slow reflow, and reperfusion arrhythmia, and improved the myocardial perfusion grade, TIMI flow during PCI and improved clinical outcomes in patients with STEMI.
- © 2013 by American Heart Association, Inc.