Abstract 14593: Circulating Matrix Metalloproteinase-3 Levels Are Higher in Males and Correlate With Body Size, But Are Decreased in Marfan Syndrome
Genetic thoracic aortic aneurysm is more severe in males than females. Tissue matrix metalloproteinases (MMPs) participate in extra-cellular matrix remodelling in aneurysm disease. Peripheral venous blood levels of MMP-3 (stromelysin-1) were measured by ELISA in duplicate in 37 unrelated controls and 37 Marfan Syndrome (MFS; 2010 Revised Ghent criteria) patients, matched for age. Variation in repeat MMP measurements was less than 10%. Aortic geometry was measured by echocardiography. Plasma MMP-3 levels were found to be higher in control males (11.9 ± 1.0 ng/ml, n=22) versus control females (6.1 ± 0.9 ng/ml, n=15) (Figure 1; p=0.0002). Plasma MMP-3 levels were also higher in control males with larger Body Surface Area (BSA), (Figure 2; r=0.57, p=0.01), while plasma MMP-3 did not correlate with BSA in control females or in MFS patients. Paradoxically, plasma MMP-3 levels were found to be significantly decreased in patients with MFS, compared to controls, both overall and when stratified by gender (Figure 1). These data contrast with atherosclerotic thoracic aneurysms, where plasma MMP-3 levels have been shown to rise. Plasma MMP-3 levels have the potential to assist in diagnosis and may be suitable to monitor response to pharmacological intervention. The higher levels of plasma MMP-3 in males may partially explain the increased severity of genetic thoracic aortopathy in males.
- © 2013 by American Heart Association, Inc.