Abstract 14513: Novel Cardiac Activation Imaging With High Spatiotemporal Resolution: An Animal Validation and Comparison Study
Introduction: Non-invasive approaches to image cardiac activation can provide important information besides the traditional intra-cardiac mapping to aid ablation therapy and cardiovascular research. We present, in this abstract, a first animal validation of our novel Cardiac Electrical Sparse Imaging (CESI) technique and the comparisons with the traditional imaging approach.
Method: Our novel CESI imaging technique can image the cardiac electrical activation throughout the myocardium preserving full temporal resolution and at high spatial resolution The imaged results were validated by simultaneous intra-cardiac transmural recording and compared with those from traditional 3D imaging approaches represented by Weighted Minimum Norm (WMN) method as partial evaluation.
Results: Paced beats (n=160) from multiple single and dual site pacing locations (n=16) on rabbit models (n=4) with simultaneous intra-cardiac transmural recording. Comparisons between imaged results and intra-cardiac mapping show a good accuracy in global propagation pattern (CC=0.81±0.1), the imaged activation initiation is close (LE=4.9±0.2mm) to the corresponding pacing sites and the temporal resolution is well preserved (Relative Temporal Shrinkage , or RTS <2%). Improvements can be observed in CC, RE, LE and RTS in comparisons with the traditional WMN method.
Conclusion: The results have shown that our high spatiotemporal resolution novel cardiac activation imaging technique can image cardiac activation three dimensionally with good concordance with measured activation in full temporal resolution and have general improved performance compared with traditional WMN approach, implying a good potential as a clinical tool in aiding EP surgeries and cardiac physiological research to help understand the mechanisms of ventricular arrhythmias.
- © 2013 by American Heart Association, Inc.