Abstract 14441: Short Term Flavonoid Administration Improves Vascular Function in Healthy Smokers
Background: Smoking is associated with impaired vascular function. Concord grape juice (CGJ), one of the richest sources of flavonoids, can modify cardiovascular risk factors. Measurement of endothelial function and arterial stiffness are well validated in large population studies as strong predictors of adverse cardiovascular outcomes. We examined the impact of CGJ on arterial wall properties in healthy smokers.
Methods: We studied the effect of a 2 weeks oral treatment with CGJ (472.8 mg total polyphenols per 8 oz (240ml)) in 26 healthy smokers on three occasions (day 0: baseline, day 7 and day 14) in a randomized, placebo-controlled, double-blind, cross-over design. Measurements were carried out before (pSm), immediately (Sm0) and 20 minutes after (Sm20) cigarette smoking. Endothelial function was evaluated by flow-mediated dilation (FMD) of the brachial artery. Carotid-femoral pulse wave velocity (PWV) was measured as an index of aortic stiffness.
Results: Compared with placebo, treatment with CGJ resulted in a significant improvement in pSm values of FMD (from 8.35±2.83% day 0 to 9.15±4.21% day 7 to 9.49±2.74% day 14, p=0.02) and PWV (from 6.13±0.61m/sec day 0 to 5.86±0.63m/sec day 7 to 5.63±0.56m/sec day 14, p=0.04). At baseline measurements, FMD was significantly decreased immediately after smoking, and remained lower than baseline 20 min after smoking for both CGJ (from 8.58±3.01% pSm to 5.66±1.97 Sm0 to 7.47±3.88% Sm20, p<0.001) and placebo group (from 8.73±3.56% pSm to 6.31±2.78% Sm0, to 8.60±4.34% Sm20, p<0.001). Compared to placebo, CGJ treatment prevented the acute smoking induced decrease in FMD in day 7 (p=0.07) and in day 14 (p=0.04). Moreover, at baseline measurements, smoking induced a significant elevation of PWV for both CGJ (from 5.98±0.67 m/sec pSm to 6.23±0.67m/sec Sm0 to 6.18±0.60m/sec Sm20, p=0.02) and placebo group (from 6.00±0.66m/sec pSm to 6.24±0.64m/s Sm0, to 6.18±0.71% Sm20, p=0.04). Treatment with CGJ prevented the smoking induced elevation of FMD and PWV, after 14 days of treatment (p=0.04 for both).
Conclusions: CGJ consumption improved endothelial function and vascular elastic properties of the arterial tree in healthy smokers and attenuated acute smoking induced impairment of arterial wall properties.
- © 2013 by American Heart Association, Inc.