Abstract 14325: Smoking and Plaque Composition in Human Peripheral Arterial Disease: Implications for Disease Progression and Thrombogenicity
Background: Smoking may play a role in the progression of atherosclerosis, calcification and thrombogenicity. However, there are scarce data evaluating smoking and plaque composition in symptomatic patients with peripheral arterial disease (PAD).
Hypothesis: Peripheral atheroma from patients with cigarette smoking is associated with increased inflammation, neovascularization, medial calcification, and organized thrombus when compared to plaques without smoking.
Methods: Sixteen plaques from smokers (16 patients) procured during peripheral interventional procedure were compared with 16 control plaques from non-smokers (16 patients). Double label immunochemistry was done to quantify inflammation and neovascularization as published previously. H & E stain slides were used to evaluate medial calcification grade, and presence of organized thrombus.
Results: See figure and table. Furthermore, linear regression analysis identified correlation between neovascularization and inflammation with smokers (R = 0.512; p =0.04).
Conclusion: Peripheral atheroma from patients with cigarette smoking is associated with increased inflammation, neovascularization, medial calcification, and organized thrombus. These results underscore the clinical relevance of smoking cessation in patients with PAD.
- © 2013 by American Heart Association, Inc.