Abstract 14309: Left Atrial Volume and Function Indices: Trends With Age and Gender
Left atrial (LA) volume is an established biomarker for underlying cardiovascular pathology and for adverse clinical outcomes. Combining LA functional parameters with LA volume has been shown to be a more powerful prognostic marker. However, there are conflicting data on the relationship with age and gender.
Methods: We used the EchoNoRMAL database, which is an individual-person meta-analysis that includes population-based echocardiographic data from 23301 adults aged 18-80 free of cardiovascular disease and/or risk factors. The effects of age and gender on LA volumes and functional parameters (LA ejection fraction (LAEF) and LA expansion index (LAEI)) was assessed using linear regression in the subset of 1089 subjects (49% women) with both minimum (LAVmin) and maximum (LAVmax) LA volumes.
Results: Mean age was 44 yrs (range 18-80yrs), mean (SD) LAVmax 42 ml (14) and LAVmin 18 ml (8). Both volumes were significantly larger in males (LAVmax: males 44 ml, females 40 ml; LAVmin: males 20 ml, females 17 ml, both p<0.0001) however LAVmax indexed to BSA was larger in females (25.3 v 23.9 ml/m2, p=0.01). There was no age associated difference in LAVmax, though LAVmin was larger with increased age (0.5 ml per 10 years). In the whole group, mean LAEF was 56% (12) and LAEI was 1.5 (0.7). There was a small yet significant decrease in LAEF with increased age (0.9% per 10 years), and in LAEI (0.06 per 10 years).
Conclusion: This study demonstrates the lack of any age related change in LAVmax in a large group of normal subjects; therefore changes in LA volume, when observed, should be regarded as consequent to underlying cardiovascular pathology. A gender-based difference in indexed and non-indexed LAVmax was observed. LA functional parameters decreased with age and may be more sensitive markers of age related changes in LV diastolic function than LA volume.
- © 2013 by American Heart Association, Inc.