Abstract 14263: The Utility of Fully Automated One-beat Real-time Three-dimensional Echocardiography in the Assessment of Left Ventricular Diastolic Function
Introduction: A novel real-time 3-dimensional echocardiography (RT3DE) allows single-beat acquisition of 3D information of left ventricle (LV), and fully automated quantification of left ventricular (LV) volume during a cardiac cycle. This study aimed to investigate the utility of LV time-volume curve derived from fully automated one-beat RT3DE in the assessment of LV diastolic function.
Methods: First, 15 patients with sinus rhythm simultaneously underwent standard 2-dimensional echocardiography (2DE), RE3DE, and cardiac catheterization to measure time constant of the isovolumic-pressure decline (τ). From LV time-volume curve obtained by RT3DE, peak early filling rate (PFR) during diastole was generated (Figure) and was indexed for the LV end-systolic volume. Second, further 527 patients who were scheduled for both 2DE and RT3DE examinations were enrolled to investigate the association between PFR index and 2DE evidenced diastolic dysfunction.
Results: In the total of 585 patients, RT3DE analysis was adequately performed in 542 patients (feasibility 93%). Of the 15 patients, τ showed significant correlation with PFR index (r=-0.65, p=0.009). Of the 527 patients, PFR index was related to age (r=-0.24, p<0.001) and e’ (r=0.41, p<0.001). PFR index decreased in proportion to the grade of 2DE evidenced diastolic dysfunction (p<0.001), with large scatter with PFR index, particularly in intermediate values. However, all patients with normal diastolic function has PFR index greater than 2.0.
Conclusions: This study demonstrated that a novel fully automated one-beat RT3DE-derived PFR index may be the diagnostic tool of choice for the assessment of LV diastolic function. Patients with PFR index less than 2.0 can be defined as having diastolic dysfunction.
- © 2013 by American Heart Association, Inc.