Abstract 14247: The cardiac-specific Troponin-I Predicts the Coronary Artery Involvement in Rheumatoid Arthritis
Introduction: Rheumatoid arthritis (RA) is associated with incremental risk of premature coronary atherosclerosis, ischemic heart disease and heart failure. Cardiac-specific troponin-I (cTn-I) is a biomarker of myocardial injury which may play a pivotal role in early detection of subclinical coronary artery involvement. This study was undertaken to test the hypothesis that cardiac-specific troponin-I (cTn-I) is an independent predicting factor of coronary artery atherosclerosis in Rheumatoid arthritis (RA).
Methods: One hundred and fifty RA subjects were enrolled and underwent the Multi-detector Computed tomography (CT) calcium scoring and non-invasive angiography. Coronary artery calcification (CAC), segmental stenosis score (SSS), segmental involvement score (SIS) and total plaque severity score (TPS) were assessed. 8 patients were excluded due to incomplete serologic data.
Results: The association of cTn-I concentrations with burden of coronary artery atherosclerosis in RA has been calculated by using the ANOVA trend analysis. There was a significant direct association between concentration of cTn-I and severity of coronary artery involvement after adjustments for age, sex, BMI, family history of heart diseases, smoking, hypertension, dyslipidemia, diabetes mellitus, prednisolone use and dose. The P-values for trend on CAC score, SSS, SIS and TPS were 0.013, 0.024, 0.019 and 0.029, respectively (Table).
Conclusion: This study demonstrates that higher cTn-I can predict incremental burden of coronary atherosclerosis (both calcified and non-calcified) in subjects with RA.
- © 2013 by American Heart Association, Inc.