Abstract 14243: Left Atrial Volume Index Independently Predicts Hypertensive Response to Exercise In Patients With Hypertension but not in Normotensive Control Subjects
Background: A hypertensive response to exercise (HRE) is associated with higher risk of future cardiovascular events. We investigated what factors are relevant to HRE in both hypertensive patients and normotensive control subjects.
Methods: 95 hypertensive patients (44 men, 59±10 years) and 60 normotensive control subjects (24 men, 54±8 years) were consecutively enrolled. HRE was defined by maximum SBP ≥ 210 mmHg in males and ≥ 190 mmHg in females. Clinical characteristics, echocardiographic and laboratory findings were assessed at the time of enrollment.
Results: HRE was more prevalent in hypertensive patients compared with normotensive control subjects (48.4% vs. 21.7%, p=0.001). Peak oxygen uptake was lower in hypertensive patients (27.8±65 vs. 30.5±6.0 mL/kg/min, p=0.002), however there was no significant difference according to HRE. Age and body mass index were shown to be associated with HRE in normotensive control subjects. Multivariate analysis revealed that left atrial volume index (LAVI) was found to be an independent predictor of HRE in hypertensive patients (p=0.003) but not in normotensive control subjects (p=0.926) when controlled for age, gender, body mass index and renal function.
Conclusions: Higher LAVI, a surrogate marker of chronic diastolic dysfunction is independently related to HRE in hypertensive patients.
- © 2013 by American Heart Association, Inc.