Abstract 14192: The Relationship of Body Fat Distribution Measured by Dual-Energy X-ray Absorptiometry With the Extent of Coronary Atherosclerosis
Background: Body fat distribution (BFD) especially, visceral fat accumulation is closely related to cardiovascular disease than the amount of total body fat itself. We aimed to evaluate the relationship between BFD and the extent of coronary atherosclerosis.
Methods: We measured total body fat and regional body fat distribution using dual-energy X-ray absorptiometery in 769 patients (445 male, age 59±10 years) who underwent their first coronary angiography. The extent of coronary atherosclerosis was assessed using Gensini score based on the quantitative coronary angiography results. The coronary artery tree was divided into 14 segments and each of these segments was scored from 1 to 32 depending on the most severe stenosis using the following system: 1 = stenosis 1% to 25%, 2 = stenosis between 26% and 50%, 4 = stenosis between 51% and 75%, 8 = stenosis 76% to 90%, 16 = stenosis 91% to 99% and 32 = total occlusion. The Gensini score was generated as the sum of the scores in all segments.
Results: Mean Gensini score of the enrolled patients was 33.1 ± 33.8. The truncal fat mass to total body fat mass ratio (FMtrunk/FMtotal) and the truncal fat mass to extremities fat mass ratio revealed positive correlation with Gensini score (r=0.196, p<0.001; r=0.165, p<0.001, respectively). In contrast, body mass index and total body fat mass did not correlate with Gensini score (r=-0.016, p=0.656; r=-0.017, p=0.768, respectively). FMtrunk/FMtotal was independently associated with Gensini score on multiple linear regression analysis (β=0.200; 95% CI, 0.130 to 0.272, p=<0.001).
Conclusions: BFD, especially FMtrunk/FMtotal representing central fat distribution is closely related to the extent of coronary atherosclerosis. More active therapeutic interventions for central fat accumulation might be essential to prevent coronary atherosclerosis.
- © 2013 by American Heart Association, Inc.