Abstract 14162: Mortality Risks by Ethnicity Based on Coronary Artery Calcium Scores at Ten Year Follow-up
Objective: Although coronary artery calcium (CAC) scores predict future mortality risk, the utility for different mortality risks based on ethnicity is unclear. We investigated the different mortality risk based on CAC by ethnicity after a mean follow-up of 10 years.
Methods: We studied 11910 consecutive asymptomatic individuals (White 9525, Hispanic/Latinos 925, Black 447 and Asian 1013) without known coronary artery disease (mean 58±12 years, 67% men) undergoing CAC scanning by non-contrast cardiac computed tomography from December 1991 to December 2010. Using multivariable Cox proportional hazard models, adjusting for age, gender, and risk factors, we evaluated all-cause mortality by race based on CAC scores between 0, 1-99, 100-399 and ≥400.
Results: CAC scores (Mean ± SD) for White, Hispanic/Latino, Black and Asian patients were 248±588,189±518, 265±720 and 210±577, respectively (p=0.001). During a mean follow-up of 10.1±3.3 years, 488 individuals (4.1%) died. Hispanic/Latino and Black patients experienced higher annualized mortality risks compared to White or Asian patients (1.9% vs. 4.3% vs. 1.3% vs. 1.4%, p<0.0001). Compared to those patients with CAC score of zero, the mortality rates were significantly higher in patients with increasing CAC scores among all ethnicity groups (Table).
Conclusion: During the mean follow-up of 10 years, CAC predicts future mortality risks among all ethnicity groups. Hispanic/Latino and Black patients are likely to have the higher mortality risks compared to White or Asian patients.
- © 2013 by American Heart Association, Inc.