Abstract 14015: Early Pathogenic Structural Heart Changes Associated With Tricuspid Regurgitation
Background: Tricuspid regurgitation (TR) is increasingly recognized for its potent impact on patient morbidity and mortality. Significant, late stage TR is well described and characterized by tricuspid annulus (TA) dilation and right ventricular enlargement, with associated papillary muscle displacement and tethering. However, the early anatomic changes of early, mild TR and its progress to significant TR are incompletely described. Improved understanding of these changes are likely important for therapeutic decisions as percutaneous tricuspid valve therapies become available. We thus examined mild/early stage TR to determine key associated cardiac structural changes.
Methods and Results: 3D CTA and echocardiographic scans from 333 clinical patients were analyzed. Cases were divided into 3 groups based on echocardiographic TR severity as follows: Group 1 (no/trace TR, n=198), Group 2 (mild TR, n=105), and Group 3 (moderate/severe TR, n=30). TA area (TAA) and volumes of the Right atrium (RA), Right ventricle (RV), Left atrium (LA) and Left ventricle (LV) were measured by 3DCT. The TAA, RA volume, LA volumes all increased directly and proportionately with increasing TR severity. RV and LV volumes were both enlarged only in significant TR. The best correlation with TAA was Right Atrial Volume (
- © 2013 by American Heart Association, Inc.