Abstract 13888: Bilirubin Levels and Risk of Prediabetes in Young and Healthy Adults
Purpose: Inflammation and oxidative stress have been implicated in the development of type 2 diabetes mellitus. We therefore assessed the relationship between levels of serum bilirubin, an endogenous antioxidant, and risk of prediabetes in young and healthy individuals.
Methods: A population-based cross-sectional study of healthy adults aged 25-41 years was performed. Individuals with known diabetes, body mass index (BMI) >35 kg/m2 and prevalent cardiovascular disease were excluded. Total bilirubin and glycosylated hemoglobin (HbA1c) were assayed from venous blood samples using a Cobas 6000 (Roche, Switzerland) and high-performance liquid chromatography (Bio-Rad D-10, Switzerland), respectively. Prediabetes was defined as HbA1c between 5.7 and 6.4%.
Results: Of 1574 participants, 27.3% had prediabetes. The median (interquartile range) levels of total bilirubin were significantly lower in prediabetics compared with individuals without prediabetes (8.6 (6.8; 13.7) vs. 10.3 (6.8; 12.0) umol/l, p<0.0001). The lower serum bilirubin levels among prediabetics were confirmed in logistic regression models, as shown in the Table. Multivariable adjustment for a broad range of potential confounders only minimally altered this relationship. In sex-specific analyses, we found that the association between bilirubin and prediabetes seemed to be stronger among men (OR (95% CI) in the highest bilirubin quartile 0.31 (0.20; 0.47), p<0.0001) compared with women (OR (95% CI) in the highest bilirubin quartile 0.71 (0.50; 1.00), p = 0.05) (p for interaction 0.003).
Conclusion: We found a highly significant inverse association between total bilirubin levels and prediabetes. These data suggest that oxidative stress may be an important factor in the early development of type 2 diabetes, especially among men.
- © 2013 by American Heart Association, Inc.