Abstract 13844: Lipoprotein Particle Number and Size Predict Vascular Structure and Function Better than Lipid Concentration in Young Subjects
In adults, dyslipidemia is associated with higher carotid intima media thickness (cIMT) and arterial stiffness. These noninvasive measures of early vascular dysfunction predict CV events. In adolescents and young adults, lipid concentrations have not been consistently and strongly associated with vascular measures. We hypothesized that nuclear magnetic resonance (NMR) measures of lipoprotein particle number (LDLp, HDLp, VLDLp) and size (LDLs, HDLs, VLDLs) would predict vascular measures more strongly than traditional lipid concentration (LDLc, HDLc, TG) in our cohort of 674 subjects mean age 18 years (10-24 years, 33% male, 39% Caucasian) who were recruited for a study of the effects of Obesity (O=228) and T2DM (T=214) as compared to Lean (L=214) controls, on CV structure and function. Traditional CV risk factors, cIMT (common, bulb, internal) and stiffness (Peterson Elastic Modulus, PEM), Augmentation Index (AIx), Pulse wave velocity (PWV) and Brachial artery distensibility (BrachD) were collected. Differences in risk factors were evaluated by ANOVA. General linear models were constructed including age, race, sex, group, BMI z-score (height for AIx only), SBP and DBP z-score for cIMT or MAP for arterial stiffness, HR, log fasting glucose, insulin, HbA1c, CRP and either traditional or NMR lipid parameters. Outcomes were log transformed for variance stabilization as needed. When stratified by group, adiposity, BP, glycemic control, traditional and NMR lipid measures worsened from L to O to T. However, LDLc was equal in O and T while LDLs differentiated the 3 groups (T>O>L, p≤ 0.0001). Models demonstrated the superiority of NMR values which entered for all vascular outcomes and explained more of the variance than traditional lipid concentration where only HDLc entered the model for BrachD (not shown). We conclude that lipoprotein particle number and size are more strongly related to vascular structure and function than traditional lipid values in young patients.
- © 2013 by American Heart Association, Inc.