Abstract 13816: Relation Between the Atrial Fibrillation and the Endothelial Function: Effect of Sinus Rhythm Restoration by Catheter Ablation
Background: Endothelial function has been shown to be correlated significantly with the severity of cardiovascular disease. Meanwhile, atrial fibrillation (AF) is an independent risk factor which worsens the cardiac function. Objectives: The purpose of this study was to elucidate the correlation between the endothelial function and AF. Thus, we examined the effect of the restoration of sinus rhythm by AF catheter ablation (CA) on the endothelial function.
Methods: The consecutive 83 patients with AF (63 paroxysmal and 20 persistent) who underwent CA for AF were included in this study. All patients assessed their endothelial function by the reactive hyperemia-peripheral arterial tonometry (RH-PAT) and the RH-PAT index (RHI) was measured before and 6 months after CA. To evaluate the relation of between AF and the endothelial function, the correlation between RHI and clinical variables were assessed by the univariate and multivariate linear regression analysis before CA. Then, the change in the RHI following CA was compared between patients with and without recurrence of AF.
Results: Before CA, 66 patients showed sinus rhythm and 17 patients showed AF. RHI in sinus rhythm was significantly higher than that in AF (1.93±0.44 vs. 1.59±0.18, p<0.001) before CA. The RHI inversely correlated with the presence of AF (r=0.330, p=0.002), persistent form AF (r=0.267, p=0.015) and renal dysfunction (r=0.266, p=0.015). The multivariate linear regression analysis revealed that there was an independent inverse correlation between the presence of AF and RHI (r=0.330, p=0.002). The RHI was significantly improved 6 months after CA (1.75±0.32 vs. 2.14±0.41, p<0.001) in patients without AF recurrence (n=60), however the RHI was significantly worsened 6 months after CA (2.13±0.53 vs. 1.80±0.34, p=0.014) in patients with AF recurrence (n=23).
Conclusion: The presence of AF was independently correlated with the impaired endothelial function. Long-term sinus rhythm restoration by CA of AF resulted in the improvement of endothelial function, whereas recurrence of AF caused an endothelial dysfunction.
- © 2013 by American Heart Association, Inc.