Abstract 13762: SDF 1 Alpha and Carotid plaque Characteristics: the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study
Objective: Stromal cell-derived factor 1 alpha [SDF1α, C-X-C motif chemokine 12, (CXCL12)] is a chemokine expressed in atherosclerotic plaques and genetic variants have been associated with both incident coronary heart disease events and plasma levels. Our goal was to assess the relationship between circulating levels of SDF1α and carotid atherosclerotic plaque burden and plaque composition.
Methods: Magnetic resonance imaging (MRI) of the carotid artery was performed in a case cohort random sample of 1901 white and black participants from the ARIC Study selected based on carotid wall thickness. Plasma levels of SDF1α were measured from blood at the same visit. Indices of carotid plaque burden and plaque composition were assessed with MRI. After excluding individuals with missing covariates we included 1420 individuals. An analysis of covariance (ANCOVA) was performed to study the associations between MRI variables and SDF1α.
Results: The mean age of study participants was 71.8 years, 17% had CHD, 4% had strokes and 24% had diabetes mellitus. In the unadjusted models individuals in the highest SDF1α tertiles had significantly higher carotid total wall volume, maximal wall thickness, vessel wall area and total vessel area. After adjustment for cardiovascular risk factors, individuals in the highest SDF1α tertile had higher total wall volume and maximal wall thickness than first tertile. No association was found with the plaque composition (see table).
Conclusion: SDF1α levels were positively associated with atherosclerosis burden. The positive association between SDF1α plasma levels and burden of disease in ARIC and the previously reported association between genetic variants in CXCL12 with atherothrombotic events suggest that further investigation is warranted in regards to mechanisms and as a potential target of therapy.
- © 2013 by American Heart Association, Inc.