Abstract 13666: Association of Paracardial Adipose Tissue With Plaque Composition in STEMI Patients Undergone Primary Percutaneous Coronary Interventions: Insight From Virtual Histology Intravascular Ultrasound Analysis
Background: The association between paracardial adipose tissue (PCAT), including epicardial adipose tissue (EAT) and pericardial adipose tissue (PAT), and atherosclerosis is well know. The impact of PCAT, however, on plaque composition of coronary artery has not been elucidated. Therefore, this study investigated to the impact of PCAT on the plaque components of coronary artery by virtual histology intravascular ultrasound (VH-IVUS).
Methods: We enrolled 155 STEMI patients who underwent primary percutaneous coronary intervention with VH-IVUS. PCAT was quantified on parasternal long and short axis view of echocardiography. Conventional- and VH-IVUS was performed to assess coronary plaque composition in the index patients. Plaque compositions were classified as fibrous, fibro-fatty, necrotic core, and dense calcium with the VH-IVUS system.
Results: Pt’s characteristics are as follows: mean age 61.1±13.0 yrs, male 83.9%, and diabetes 11%. On stratification of our patients into 2 groups using the mean (34.36±10.94 mm) value of PCAT as the cutoff, the patients in the greater than mean for PCAT (group 2) had a larger fat mass and lower DM patients than the other group (group 1); however, no significant differences were found in age, and other risk factors (Table). There were no significant differences between 2 groups in vessel area, lumen area, plaque burden, remodeling index, and frequency of thin-cap fibroatheroma. VH-IVUS showed that absolute area(p=0.008) and relative amoun (p=0.023) of calcium components were significant larger in group 2 than group 1 (Table). Of note, absolute calcium area was an independent predictor of high PCAT (odds ratio 19.37, 95% CI 1.19-316.71, p=0.038).
Conclusion: The more PCAT was associated with the larger amount of calcium component in STEMI patients and vice versa. This finding supports that increased epicardial fat may contribute to the progression of atherosclerotic plaques, especially calcium composition.
- © 2013 by American Heart Association, Inc.