Abstract 13366: Prevalence and Risk Factors of Renal Artery Stenosis in Patients With Resistant Hypertension
Introduction: Renal artery stenosis (RAS) is a common cause of secondary hypertension. Renal artery angiography is the gold standard for diagnosting RAS. The aim of this study is to report 1) the prevalence of RAS in patients with resistant hypertension and 2) the association of RAS with peripheral vascular disease (PVD) and diabetes mellitus (DM).
Methods and Results: We studied 285 consecutive patients (Mean age: 72.5) with resistant hypertension (systolic blood pressure > 140mmHg despite administration of at least 3 antihypertensive drugs) who underwent renal artery angiography at Baylor Heart and Vascular Hospital between January, 2006 and December, 2010. RAS was diagnosed if the angiographic luminal narrowing was greater than or equal to 50% by direct visual inspection. 69 cases of RAS were identified (incidence 24.2%). The propensity-adjusted analysis (controlling for clinical and non-clinical risk factors) showed a strong and significant association between RAS and PVD (Odds Ratio [OR]: 5.15; 95% confidence intervals [CI], 2.68, 9.89; p-value<0.0001). However, the association between RAS and DM, a previously defined risk factor for RAS, was not significant in this cohort (OR: 0.63; 95%CI: 0.34, 1.19; p-value= 0.158).
Conclusion: Results from this retrospective registry define the prevalence of RAS in patients with resistant hypertension. Patients with PVD were found to be 5 times more likely to experience RAS than patients without PVD while DM did not confer any increased risk.
- © 2013 by American Heart Association, Inc.