Abstract 13339: Isolated Minor Electrocardiographic T-wave Abnormalities and Cardiovascular Mortality in Subjects With and Without Hypertension
Background: Isolated minor T-wave abnormalities not accompanied by ST segment abnormalities or findings of left ventricular (LV) hypertrophy are frequently observed in the general population and their prognostic value is less clear as ST segment abnormalities. However, it may depend on presence or absence of hypertension.
Methods: Associations of cardiovascular mortality with the isolated minor T-wave abnormalities were studied in citizens who received ECG in the health examination of Moriguchi city, Osaka, Japan in 1997, stratified by presence or absence of hypertension. ECGs were read by 3 cardiologists with the judgment of minor or major abnormalities blinded to any clinical information including blood pressure except for age and sex. Subjects with any major abnormalities on the ECG, history of cardiovascular disease, left bundle branch block, intraventricular conduction delay, or non-sinus rhythm were excluded.
Results: There were 13,297 subjects and 4,301 subjects had hypertension. Mean age was 58± 10 years with 26% of men. The isolated minor T-wave abnormalities were observed in 226 subjects (118 without hypertension, 108 with hypertension) and included 4 of Minnesota Code (MC) 5-2, 45 of MC 5-3, and 177 of MC 5-4. During a mean follow-up of 12.8± 3.4 years, there were 302 cardiovascular deaths. By multivariate proportional hazards regression analyses after adjustment for age, sex, diabetes, smoking, alcohol drinking, and hypercholesterolemia, subjects with the isolated minor T-wave abnormalities had significantly higher cardiovascular mortality compared to those without any ST-T abnormalities or LV hypertrophy in hypertensives (relative risk (RR)=2.53, 95% confidence interval (CI)=1.23-5.19, p=0.0115), whereas they were not significantly associated with cardiovascular mortality in non-hypertensives (RR=1.68, 95%CI=0.41-6.83, p=0.4708).
Conclusions: Isolated minor T-wave abnormalities predicted cardiovascular mortality in subjects with hypertension, whereas they didn’t in those without hypertension.
- © 2013 by American Heart Association, Inc.