Abstract 13268: Trans-Fat Intake and Incidence of Stroke in the Reasons for Geographical and Racial Differences in Stroke Cohort
Background: Whether elevated intake of trans-fatty acids (TFA) increases the risk for stroke remains unclear. Except for the Women’s Health Initiative-Observational Study, most studies that directly assessed the association between TFA intake and stroke yielded null results.
Methods and Results: We investigated the association between TFA intake and stroke incidence among black and white men and women (n=17,116) from the REasons for Geographic and Racial Differences in Stroke cohort. From 2003 to 2007, participants were recruited from the continental United States and followed for incident stroke. Cox regression was used to test whether energy-adjusted TFA intake in 1 standard deviation (SD) increments was associated with incident stroke. During a median follow-up of 7 years, 479 strokes were identified, including 401 ischemic strokes. Sex modified the association between TFA intake and stroke (P for interaction = 0.06) and thus results were stratified by sex. After adjusting for age, sex, smoking status, race, region, alcohol use, education, waist circumference, level of physical activity, diabetes, coronary heart disease, hypertension, heart failure, chronic kidney disease, statin use, regular aspirin use, total energy and intake of energy-adjusted saturated fat, monounsaturated fat, polyunsaturated fat and proteins, each 1 SD (2 g/d) higher trans-fat intake was associated with increased risk of any stroke among men (HR = 1.14; 95% CI: 1.02-1.28) but not among women (HR = 0.93; 95% CI: 0.79-1.11). In fully adjusted models, similar results were obtained for ischemic stroke among men (HR = 1.13; 95% CI: 1.00-1.28) and women (HR = 0.93; 95% CI: 0.77-1.12).
Conclusion: We show for the first time that sex modifies the association between TFA intake and stroke. For every 2 g/d higher trans-fat intake, there was a 14% increase in the risk of stroke among men but not women.
- © 2013 by American Heart Association, Inc.