Abstract 13261: Maintaining High Physical Activity in Young Adulthood is Associated With Lower Cardiovascular Disease (CVD) and Non-CVD Mortality through Middle Age: the Coronary Artery Risk Development in Young Adults (CARDIA) Study
Background: Physical activity (PA) is associated with cardiovascular (CVD) mortality, but data on associations between long-term PA patterns and mortality are sparse. We analyzed the associations between young adulthood patterns of PA and adulthood mortality through middle age.
Methods: At six CARDIA exams over 15 years, 3,648 participants (ages 18-30 at baseline in 1985-1986) reported frequency of participation in 13 specific physical activities. PA was expressed as exercise units (EU), with 300 EU approximating 150 min/week of moderate-intensity jogging. Group-based trajectory modeling was used to identify trajectories of PA from year 0 to 15 dependent on the likelihood of maintaining 300 EU at each exam. The optimal number of trajectories was identified by comparing the Bayesian Information Criteria. Follow-up time was calculated from exam year 15 (2001-2002) through 2011 (ages 33-45 to 43-55). Cox regression models were used to test the association of PA patterns with CVD and non-CVD mortality.
Results: We identified 4 trajectories of PA: always sedentary (27.9%), declining (11%), mostly active (36.7%) and always active (24.4%). As compared with those who were always sedentary, always active and mostly active participants exhibited lower CVD mortality (Table). Findings were similar by race [black vs. white] (p=0.79) and gender (p=0.65). The always active also experienced significantly lower non-CVD mortality.
Conclusions: Adults who consistently maintain recommended levels of PA through young adulthood exhibit lower CVD mortality than adults who are always sedentary or whose physical activity levels decline from young adulthood through middle age. Being consistently sedentary may predispose to premature CVD mortality while being mostly or always active over 15 years appears to protect against CVD mortality.
- © 2013 by American Heart Association, Inc.