Abstract 13208: Seasonal Discrepancy in the Correlation between Vitamin D and Omega-3 Index in Patients With Acute Coronary Syndrome from Western Norway
Background: Several studies have demonstrated an inverse relationship between cardiovascular risk and levels of vitamin D and omega-3 index.
Objectives: To assess the seasonal correlation between vitamin D measured as 25-hydroxyvitamin D [25(OH)D] and the omega-3 index (eicosapentaenoic acid + docosahexaenoic acid) in packed red blood cells in patients with acute coronary syndrome (ACS) recruited from western Norway.
Methods: Blood samples for 25(OH)D and omega-3 index analyses were harvested on admission in 457 patients with ACS defined by a troponin T (TnT) value ≥ 0.01 ng/ml. Seasonal (summer: April - September and winter: October - March) correlations between 25(OH)D and omega-3 index were evaluated.
Results: There were statistically significant seasonal differences between mean(SD) 25(OH)D levels: 54.7(19.3) nM from October through March (n = 190) and 50.8(18.9) nM from April through September (n = 267); p = 0.032. Corresponding levels of the omega-3 index were 6.6(2.0) % and 6.8(2.1) %, respectively; p = 0.27. There was a positive correlation between 25(OH)D and the omega-3 index during both seasons; Spearman’s rank correlation coefficients were 0.244, p < 0.0001 for April - September (figure 1) and 0.366, p < 0.0001 for October - March (figure 2).
Conclusion: Significantly higher vitamin D levels and a stronger correlation between vitamin D and the omega-3 index were noted during the winter season, despite no seasonal difference in the omega-3 index. This may reflect a seasonal variations in the content of vitamin D in fish products and/or more effective vitamin D absorption during the winter season.
- © 2013 by American Heart Association, Inc.