Abstract 13195: Frailty With Risk of Incident Heart Failure in Older Adults
Background: Frailty is common in the elderly and is associated with adverse health outcomes. Impact of frailty on risk of HF is not known. The primary objective of this study is to assess the association between frailty and risk for heart failure (HF) in older adults.
Methods: We assessed the association between frailty, using the Health ABC Short Physical Performance Battery (HABC battery) and the Gill index, and incident HF in 2825 participants aged 70-79 years.
Results: Mean age of participants was 74±3years; 48% were men and 59% were white. During a median follow up of 11.4 (7.1-11.7) years, 466 participants developed HF (17.7 per 1000 person-years), Figure 1A. Compared to non-frail participants, moderate (hazard ratio HR 1.36, 95%CI 1.08-1.71) and severe frailty (HR 1.88, 95%CI 1.02-3.47) as defined by Gill index was associated with a higher risk for HF. HABC battery score was linearly associated with HF risk, (Figure 1B) after adjusting for the Health ABC HF Model (HR 1.24, 95%CI 1.13-1.36 per SD decrease in score), and remained significant when controlled for death as a competing risk (HR 1.30; 95%CI 1.00-1.55). Results were comparable across age, sex, and race, and in sub-groups based on diabetes mellitus or cardiovascular disease at baseline. Addition of HABC battery scores to the Health ABC HF Risk Model improved discrimination (change in C- index, 0.014; 95%CI 0.018-0.010) and appropriately reclassified 13.4% (NRI 0.073, 95%CI 0.021-0.125; P=0.006) of participants (8.3% who developed HF and 5.1% who did not).
Conclusion: Frailty is independently associated with risk of HF in older adults.
- © 2013 by American Heart Association, Inc.