Abstract 13151: Gestational Hypertension May be a Good Clue to Predict Developement of Left Ventricular Dysfunction
Background: Peripartum cardiomyopathy (PPCM) is known as a rare cause of heart failure affecting pregnant women without any history of cardiac disease. However, we don’t have any clues to predict an occurrence of PPCM.
Purpose: We sought to identify in pregnant women which clinical characteristics might predict who will develope an impaired left ventricular (LV) systolic or diastolic function during pregnancy and/or postpartum period.
Methods: A consecutive series of 541 high risk pregnant women who had any condition such as gestational hypertension, twin pregnancy, tocolytic therapy, and/or ≥35 years of age without any history of cardiac disease underwent echocardiographic studies and blood samplings at several time-points between 16-week of pregnancy and 6-month after delivery.
Results: PPCM actually occurred in 1.7% of cases. The frequency of LV systolic dysfunction defined as LV ejection fraction <55%, LV diastolic dysfunction suggested as the ratio of mitral E velocity to E’ (E/E’) ≥15 and brain natriuretic peptide (BNP) levels >100 pg/mL were 4.6%, 7.6% and 20.0%, respectively. Multivariate regression analysis revealed that gestational hypertension was independently associated with a higher E/E’ and BNP level. (See Table)
Conclusions: In this high risk popularion, the frequency of PPCM was higher than those reported previously. Our results also suggest that an LV diastolic dysfunction may be commonly observed during peripartum period, which can be associated with gestational hypertension.
- © 2013 by American Heart Association, Inc.