Abstract 13111: Cardiac Morphology and Function Reference Values in Healthy Young Adults by Magnetic Resonance Imaging
Background: Assessment of cardiac anatomy (mass, volumes) and function by steady-state free precession (SSFP) cardiovascular magnetic resonance (CMR) is accurate and reproducible. Normal reference values exist for various subsets of population, but are lacking in a large sample of young healthy adults.
Methods: A sample of 525 Caucasian young adults (48% males) without cardiovascular risk factors and disease, aged between 18 and 36, underwent CMR. Mean anthropometric measurements, blood pressure and blood markers (including brain natriuretic peptide) were all within the normal limits and typical of a low cardiometabolic risk profile. Ventricular and atrial volumes, function and left ventricle (LV) mass were measured in the end-diastolic (ED) and end-systolic (ES) phases on short-axis SSFP cine imaging covering the entire cardiac silhouette.
Results: Mean age was 26.4 ± 4.4 years. ES, ED and stroke volumes were lower in females compared to males in all cardiac chambers (174 ± 30 vs 129 ± 19 ml for LV-ED, 197 ± 36 vs 142 ± 25 ml for right ventricle (RV)-ED, 81 ± 19 vs 64 ± 15 ml for left atria (LA)-ES and 110 ± 26 vs 80 ± 18 ml for right atria (RA)-ES, all p-values <0.001). After indexing to body surface area (BSA), these values were still significantly higher in males (89 ± 12 vs 78 ± 8 ml/m2 for LV-ED, 101 ± 15 vs 85 ± 12 ml/m2 for RV-ED, 41 ± 8 vs 38 ± 7 ml/m2 for LA-ES and 56 ± 12 vs 48 ± 9 ml/m2 for RA-ES, all p-values <0.001). Ejection fraction for both ventricles was similar in males and females (65 ± 5 % for LV and 62 ± 7 % for RV) while it was lower in males compared to females in both atria. LV mass was superior in males than in females (128 ± 25 vs 83 ± 16 g/m2, p<0.01). Wall thickness of each segment was lower in females than in males whereas wall thickening was similar in both genders. After adjustment for gender and BSA, age was an independent determinant of LA and both ventricle volumes. A decrease in ventricular volumes and an increase in LA volumes were observed with aging. In contrast, LV mass was not associated with age in our population.
Conclusion: This is the first large database of reference ranges for ventricular and atrial function, volume and mass in young and healthy males and females. These data will allow accurate interpretation of clinical and research CMR exams for this population.
- © 2013 by American Heart Association, Inc.