Abstract 12978: Genetic Status of Estrogen Receptor Modifies the Relation of Postmenopausal Hormone Therapy with Carotid Atherosclerosis Among Older Postmenopausal Women. The Three-city Cohort Study
Background: Epidemiological data have shown that postmenopausal hormone therapy (HT) may have a beneficial impact on atherosclerosis. Estrogen effects are mediated by their receptors, the activity of which can be modulated by genetic polymorphisms. However, the association of HT use with atherosclerosis has not been studied according to the genetic status of estrogen receptors.
Objectives: To investigate the influence of estrogen receptors genetic polymorphisms on the association of HT use with carotid atherosclerosis among postmenopausal women
Methods: In the French prospective Three-City cohort study, data on carotid ultrasonography and genetic status were available for 3.843 women over 65 years of age. Standardized procedures were used to determine carotid intima-media thickness (IMT) in plaque-free site and atheroma plaques as well as to genotype estrogen receptors for several polymorphisms (rs2234693, rs9340799, rs1256049, rs4986938, rs1271572). The association of HT use with atheroma plaques and IMT, as well as potential interactions with genetic polymorphisms, were assessed by logistic and linear regressions.
Results: After adjustment for cardiovascular risk factors, current HT use decreased the risk of atheroma plaque (OR=0.82; 95 %CI: 0.67-0.99) and this association did not differ according to the characteristics of HT. In addition, the risk of atheroma plaque associated with current HT use depended on rs9340799 genetic polymorphism. Compared to non users, OR for atheroma plaque in current HT users was 0.78 (0.62-0.97) among carriers of allele A and 1.24 (0.69-2.25) among carriers of GG genotype (p for interaction=0.02). In contrast, our data showed no independent association of HT use with carotid IMT without any interaction with genetic status.
Conclusion: Current HT use may prevent atheroma plaque among postmenopausal women but this beneficial effect could depend on genetic status of estrogen receptor.
- © 2013 by American Heart Association, Inc.