Abstract 12965: Moderate Sleep Deprivation Leads to Impairment in Endothelial Function Independent of Weight Gain
Introduction: Endothelial dysfunction promotes atherosclerosis and may be a precursor of overt cardiovascular disease. Acute total sleep deprivation appears to impair endothelial-dependent vasodilation but the applicability of this finding to real-world short sleep has yet to be determined. We hypothesized that prolonged moderate sleep loss in healthy individuals results in endothelial dysfunction.
Methods: Sixteen healthy subjects (10 male; age 24.6±5 y; BMI 22.5±1.9 kg/m2) underwent a 15-day inpatient protocol. After a 3-day acclimation period, participants were randomized to 8 days of either sleep deprivation (defined as one-third reduction of their habitual sleep) or normal sleep, followed by 4 days of recovery. Access to food was allowed ad libitum throughout the study. Measurements of endothelial function by brachial artery flow-mediated dilation (FMD, %) were performed at the end of each study period.
Results: As a result of the sleep manipulation, participants randomized to sleep restriction reported a 59.7±63.5 min reduction in total sleep time (Acclimation vs Experimental period, P=0.033). Compared to the acclimation phase, FMD decreased during the experimental phase in the sleep deprived group (8.6±4.6 % vs 5.2±3.4 %, P=0.008), while it remained unchanged in controls (5.04±3 % vs 6.73±2.94 %, P=0.109). There was no effect of short sleep on blood pressure. A substantial 1.1±1.1 kg weight gain (P=0.039) occurred during sleep curtailment. Correlations among changes in FMD, weight and blood pressure did not reveal any significance.
Discussion: Exposure of healthy individuals to intermediate-duration moderate sleep loss resulted in a substantial reduction in endothelial function independent of weight gain. Chronic insufficient sleep, as increasingly experienced in everyday life, may contribute per se to raise the cardiovascular vulnerability in the general population.
- © 2013 by American Heart Association, Inc.