Abstract 12945: Correlation Between Left Atrial Epicardial Adipose Tissue Volume and Acute Effects of Colchicine Treatment after Atrial Fibrillation Ablation
Background: It has reported that epicardial adipose tissue (EAT) activated pro-inflammatory cytokines and EAT was associated with the development of atrial fibrillation (AF). Immediate recurrence of atrial fibrillation (AF) after AF ablation was related with inflammatory response. The treatment of colchicine after AF ablation suppressed the inflammatory reaction. The purpose of this study was to assess the association with the anti-inflammatory effect of colchicine after AF ablation and left atrium (LA)-EAT volume.
Methods: We studied 87 patients (64 years, 57 males, 58 with paroxysmal AF) who underwent catheter ablation for AF and received multidetector-computed tomography before the ablation. LA-EAT volume was measured by semi-automatically tracing axial images from LA roof to the coronary sinus. Thirty-six patients of them received colchicine treatment with 0.5 mg/day for 2 weeks from one day after catheter ablation. The study patients were divided into two groups: low LA-EAT group (n=44, LAEAT ≤ 23.6 cm3) and high LA-EAT groups (n=43, LA-EAT > 23.6 cm3). In each group, we investigated the anti-inflammatory effect of the colchicine treatment at 2 days, 2, 4 and 12 weeks after the procedures and the association with the incidence of AF recurrence and colchicine treatment.
Results: Baseline characteristics were well balanced between the two groups. In low LA-EAT group, colchicine treatment reduced significantly CRP levels 2 days after ablation, while in high LA-EAT group, there were no significant differences of CRP level between non-colchicine group and colchicine group (table). In each group, the incidences of AF recurrence were similar regardless of colchicine treatment.
Conclusion: The treatment of colchicine after catheter ablation for AF could suppress the acute inflammatory reaction in the AF patients with low LA-EAT.
- © 2013 by American Heart Association, Inc.