Abstract 12917: Polymorphism at the Tnf-alpha Gene Promoter Interacts with Mediterranean Diet to Influence Triglyceride Metabolism and Inflammation Status in Metabolic Syndrome Patients: From the Cordioprev Clinical Trial
Several polymorphic sites have been studied for their potential use as risk markers for T2DM (type 2 diabetes mellitus) and MetS (metabolic syndrome). In this regard, TNF-alpha is a proinflammatory cytokine involve in the regulation of a wide spectrum of biological processes.
Hypothesis and methods: our aim was to examine whether the chronic consumption of a MedDiet (mediterranean diet) enriched in olive oil (35% fat: 22% monounsaturated; 6% polyunsaturated; 7% saturated) compared with a low fat diet (28% fat: 12% monounsaturated; 8% polyunsaturated; 8% saturated) interacts with two candidate SNPs at the TNF-alpha gene promoter in order to improve triglyceride metabolism and inflammation markers. Two polymorphisms (rs1800629, rs1799964) at the TNF-alpha gene, biochemical measurements, dietary intervention and a fat load test were determined among 581 MetS patients fromCordioPrev clinical trial (NCT00924937).
Results: At baseline, individuals carrying the G/G genotype at the rs1800629 polymorphism, displayed higher fasting (P=0,003) and postprandial (P=0.025) TG (triglycerides), apoB (apo lipoprotein B) (P=0,01) and hsCRP (high sensitivity C-reactive protein) (P=0,003) plasma concentrations than did carriers of the minor A-allele (G/A + A/A). After 12 months of MedDiet intervention, we observed that baseline differences between genotypes disappeared. Specifically, during the consumption of this diet, the decrease in plasma TG and hsCRP concentrations was more intense in G/G subjects compared with carriers of the minor A allele (P=0,005 and P=0,034, respectively). No other gene-diet interactions were observed in low fat group.
Conclusions: These results suggest that the rs1800629 at the TNF-alpha gene interacts with MedDiet to influence TG metabolism and inflammation status in MetS subjects. Understanding the role of diet in optimizing TG metabolism and inflammation may be the best strategy for personalized treatment of MetS and may facilitate the choice of more effective and specific measures for prevention.
- © 2013 by American Heart Association, Inc.