Abstract 12914: Impact of Angina Frequency on the Health-Related Quality-of-Life of Patients With Chronic Angina
Background: Chronic angina is a highly symptomatic disease that can have a profound impact on patients’ health-related quality-of-life (HrQoL). The aim of this study was to quantify the relationship between angina frequency and HrQoL.
Methods: This was a post-hoc analysis from the 6-week double-blind treatment phase of the Efficacy of Ranolazine in Chronic Angina (ERICA) trial which evaluated 565 patients with stable coronary disease reporting ≥3 angina attacks/week. Angina frequency was classified using the Seattle Angina Questionnaire angina frequency (SAQAF) domain (scores of 100=no; 61-99=monthly; 31-60=weekly; 0-30=daily angina symptoms). HrQoL was assessed based on EuroQol (EQ)-5D scores derived using individual patient data from the ERICA trial and a previously published mapping equation. Median (25%, 75% range) EQ-5D scores for each angina frequency classification at the end of the 6-week period were calculated. Additionally, changes in EQ-5D scores from baseline to end-of-trial for patients achieving and not achieving a ≥20 point improvement in SAQAF score (previously reported as a minimally important improvement) were compared.
Results: Both SAQAF and EQ-5D scores were available in 548 patients (97% of all randomized) (Table). The total population reported a median EQ-5D score of 0.68 (0.62, 0.77). Compared to patients reporting no angina symptoms, patients reporting monthly, weekly and daily angina symptoms had significantly poorer HrQoL (p≤0.001 for all). Patients who improved ≥20 points on the SAQAF from baseline (n=369, 67%) experienced a median 0.08 greater improvement in EQ-5D score compared to those not achieving a ≥20 point improvement (p≤0.001).
Conclusions: Among patients suffering from chronic angina, HrQoL decreases as angina frequency increases. Patients reporting at least a minimally important improvement in angina frequency experience a tangible improvement in HrQoL.
- © 2013 by American Heart Association, Inc.