Abstract 12813: Left Atrial Appendage Flow Velocity can Predict Clinical Outcomes Following Catheter Ablation for Persistent Atrial Fibrillation
Background: Although catheter ablation is efficacious for the rhythm control of atrial fibrillation (AF), success rates vary among persistent AF. We investigated if pre-procedural parameters including left appendage flow velocity (LAV) were associated with clinical outcomes.
Methods: Fifty consecutive patients who underwent extensive pulmonary vein isolation, linear ablation at the left atrial roof and cavotricuspid isthmus were enrolled (age: 65.4±1.18 years; AF persistence: 4.14±0.75 years). Standard transthoracic and transesophageal echocardiography were performed before ablation. LAV and classical factors (AF duration, CHA2DS2VASc score, left atrial diameter and volume, left ventricular ejection fraction) were tested using Cox proportional hazards regression analysis as predictors of sinus rhythm restoration during ablation and of freedom from AF recurrence during 1-year follow-up.
Results: During the first 12 months, 21 patients (42%) developed AF recurrence, of which low LAV (≤ 0.27 cm/s) was an independent predictor (hazard ratio 3.24, 95% confidence interval 1.24-8.48; P = 0.017). Kaplan-Meier analysis obtained a higher recurrence of atrial fibrillation rate in the low LAV group than in the high LAV group. (log rank, P = 0.006).
Conclusion: Low LAV was associated with a poor outcome after catheter ablation for persistent AF. Addition of pre-procedural LAV measurement to classical factors can better predict clinical outcomes following catheter ablation for persistent AF.
- © 2013 by American Heart Association, Inc.